JNJ-7777120

Modify Date: 2024-01-02 18:39:20

JNJ-7777120 structure	Common Name	JNJ-7777120
	CAS Number	459168-41-3	Molecular Weight	277.749
	Density	1.3±0.1 g/cm3	Boiling Point	477.0±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆ClN₃O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	242.3±28.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of JNJ-7777120

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptorin vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2]in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3]

Name	1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine
Synonym	More Synonyms

Description	JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptorin vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2]in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology
References	[1]. Jablonowski JA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-3960. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ-7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-316. [3]. Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-413.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

References

[1]. Jablonowski JA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-3960.

[2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ-7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-316.

[3]. Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-413.

Density	1.3±0.1 g/cm3
Boiling Point	477.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₆ClN₃O
Molecular Weight	277.749
Flash Point	242.3±28.7 °C
Exact Mass	277.098175
PSA	39.34000
LogP	0.69
Appearance of Characters	solid \| white
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.656
Storage condition	Store at +4°C
Water Solubility	H2O: insoluble

JNJ-7777120 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3

methylpiperazine

CAS#:109-01-3

5-Chloroindole-...

CAS#:10517-21-2

~81%

JNJ-7777120

CAS#:459168-41-3

Literature: Lazewska, Dorota; Karolak-Wojciechowska, Janina; Kolesinska, Beata; Kaminski, Zbigniew; Kiec-Kononowicz, Katarzyna Heterocyclic Communications, 2011 , vol. 17, # 5-6 p. 207 - 210

Precursor 2
CAS#:109-01-3 methylpiperazine CAS#:10517-21-2 5-Chloroindole-...
DownStream 0

Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.

Microcirculation 22 , 237-48, (2015)

The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated ...

Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration.

Br. J. Pharmacol. 171(15) , 3754-63, (2014)

The present treatment for choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is not sufficient. Hence, we examined the therapeutic efficacy of reducing histamine...

Analysis of the histamine H2-receptor in human monocytes.

Biochem. Pharmacol. 92(2) , 369-79, (2014)

Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-c...

Methanone, (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-

(5-Chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)methanone

JNJ-7777120

(5-chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone

(5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone

1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: JNJ-7777120
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: JNJ-7777120
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: JNJ-7777120
Price: $350.0/100mg $630.0/250mg $1300.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: JNJ-7777120
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $86/10mM*1mLinDMSO

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JNJ-7777120

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