GW438014A

Modify Date: 2024-02-26 10:27:09

GW438014A Structure
GW438014A structure
Common Name GW438014A
CAS Number 469861-49-2 Molecular Weight 437.51
Density N/A Boiling Point N/A
Molecular Formula C23H23N3O4S Melting Point N/A
MSDS Chinese Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of GW438014A


GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].

 Names

Name N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate (1:1)
Synonym More Synonyms

 GW438014A Biological Activity

Description GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].
Related Catalog
In Vivo GW438014A (10 mg/kg; i.p.; daily, for 7 d) 抑制大鼠和食物剥夺的遗传性肥胖 ob/ob 小鼠的自发和过夜禁食诱导和 NPY 诱导的摄食[1]。 Animal Model: obese ob/ob mice[1] Dosage: 10 mg/kg Administration: intraperitoneal injection; daily, for 7 d Result: Decreased the rate of weight gain in both lean and obese rats.
References

[1]. Daniels AJ, et, al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54.  

 Chemical & Physical Properties

Molecular Formula C23H23N3O4S
Molecular Weight 437.51
Storage condition -20°C

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T+
RIDADR UN 2811 6.1 / PGIII

 Synonyms

Benzamide, N-[1-(2-phenylethyl)-1H-benzimidazol-2-yl]-, methanesulfonate (1:1)
N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate (1:1)