24(S)-Hydroxycholesterol

Modify Date: 2024-01-05 18:39:40

24(S)-Hydroxycholesterol structure	Common Name	24(S)-Hydroxycholesterol
	CAS Number	474-73-7	Molecular Weight	402.653
	Density	1.0±0.1 g/cm3	Boiling Point	513.1±23.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₆O₂	Melting Point	174-176°C (lit.)
	MSDS	N/A	Flash Point	213.5±17.2 °C

Use of 24(S)-Hydroxycholesterol

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

Name	(24S)-24-hydroxycholesterol
Synonym	More Synonyms

Description	24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	Human Endogenous Metabolite
References	[1]. Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209. [2]. M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87. [3]. Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300.

Density	1.0±0.1 g/cm3
Boiling Point	513.1±23.0 °C at 760 mmHg
Melting Point	174-176°C (lit.)
Molecular Formula	C₂₇H₄₆O₂
Molecular Weight	402.653
Flash Point	213.5±17.2 °C
Exact Mass	402.349792
PSA	40.46000
LogP	7.66
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.536
Storage condition	20°C

24S-hydroxycholesterol

Cholest-5-ene-3,24-diol

cholest-5-en-3beta,24S-diol

Cholest-5-ene-3,24-diol, (3β,24S)-

cholest-5-ene-3b,24a-diol

(3b,24S)-Cholest-5-ene-3,24-diol

24(S)-hydroxycholesterol

(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

(3β,24S)-Cholest-5-ene-3,24-diol

24S-Cholest-5-ene-3b,24-diol

24S-OHC

Cerebrosterol

24-hydroxycholesterol

24S-Hydroxy-cholesterol