Isochondrodendrine

Modify Date: 2024-01-08 07:05:21

Isochondrodendrine Structure
Isochondrodendrine structure
 Common Name Isochondrodendrine
CAS Number 477-62-3 Molecular Weight 594.69700
Density 1.239g/cm3 Boiling Point 689ºC at 760 mmHg
Molecular Formula C36H38N2O6 Melting Point N/A
MSDS N/A Flash Point 370.5ºC

 Use of Isochondrodendrine


Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum[1].

 Names

Name Isochondrodendrine
Synonym More Synonyms

 Isochondrodendrine Biological Activity

Description Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum[1].
Related Catalog
Target

Plasmodium falciparum[1]
In Vivo Isochondrodendrine has strong in vitro antiplasmodial activity against the chloroquine resistant strain FMC29 of Plasmodium falciparum. Toxicity observed is 50 to 100 fold greater towards Plasmodium falciparum than cultured L6 cells[1].
References

[1]. Mambu L, et al. Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina. Planta Med. 2000 Aug;66(6):537-40.

 Chemical & Physical Properties

Density 1.239g/cm3
Boiling Point 689ºC at 760 mmHg
Molecular Formula C36H38N2O6
Molecular Weight 594.69700
Flash Point 370.5ºC
Exact Mass 594.27300
PSA 83.86000
LogP 6.43220
Vapour Pressure 1.28E-19mmHg at 25°C
Index of Refraction 1.619

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GT8815000
CHEMICAL NAME :
Cycleanine, O(sup 7),O(sup 7')-didemethyl-
CAS REGISTRY NUMBER :
477-62-3
LAST UPDATED :
198411
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C36-H38-N2-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1001 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 7,569,1949
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
371 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 7,569,1949

 Precursor & DownStream

Precursor  0

DownStream  2

 Synonyms

Isobebeerine
d-Isochondodendrine
Isochondodendrine
Isochondodendrin
Isobebeerin
Isochondrodendrin
O7,O7'-didemethyl-cycleanine
O7,O7'-Didesmethyl-cycleanin
6,6'-dimethoxy-2,2'-dimethyl-cycleanane-7,7'-diol
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Related Compounds: More...
O-methyl-isochondrodendrine
478-63-7
O,O'-dimethyl-isochondrodendrine
30745-31-4
O,O'-dimethyl-isochondrodendrine
518-94-5
Chemsrc provides Isochondrodendrine(CAS#:477-62-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Isochondrodendrine are included as well.>> amp version: Isochondrodendrine

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