PHA-543613 structure
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Common Name | PHA-543613 | ||
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CAS Number | 478149-53-0 | Molecular Weight | 271.31 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C15H17N3O2 | Melting Point | N/A | |
MSDS | USA | Flash Point | N/A |
Use of PHA-543613PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2]. |
Name | N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide |
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Synonym | More Synonyms |
Description | PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2]. |
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Related Catalog | |
Target |
Ki: 8.8 nM (α7 nAChR)[1] |
In Vivo | PHA-543613 (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats[2]. |
References |
Molecular Formula | C15H17N3O2 |
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Molecular Weight | 271.31 |
Exact Mass | 307.10900 |
PSA | 58.37000 |
LogP | 2.78260 |
RIDADR | NONH for all modes of transport |
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Precursor 9 | |
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DownStream 0 |
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N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide,hydrochloride |