Indican

Modify Date: 2024-01-02 14:32:19

Indican Structure
Indican structure
Common Name Indican
CAS Number 487-60-5 Molecular Weight 295.288
Density 1.6±0.1 g/cm3 Boiling Point 606.7±55.0 °C at 760 mmHg
Molecular Formula C14H17NO6 Melting Point 57-58ºC
MSDS USA Flash Point 320.7±31.5 °C

 Use of Indican


Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

 Names

Name indican
Synonym More Synonyms

 Indican Biological Activity

Description Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].
Related Catalog
In Vivo Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1]. Animal Model: Male Spraguee Dawley rats weighing 330-400 g[1] Dosage: 20, 40 mg/kg Administration: Orally Result: Increased the systemic exposure and multidrug resistance-associated protein (MRP) of Methotrexate (MTX; 5.0 mg/kg).
References

[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140.

[2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 606.7±55.0 °C at 760 mmHg
Melting Point 57-58ºC
Molecular Formula C14H17NO6
Molecular Weight 295.288
Flash Point 320.7±31.5 °C
Exact Mass 295.105591
PSA 115.17000
LogP -0.75
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.715
Storage condition −20°C
Water Solubility H2O: 0.1 M at 20 °C, clear to slightly hazy, colorless to faint yellow-green

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles5

More Articles
A modified m-CP medium for enumerating Clostridium perfringens from water samples.

Can. J. Microbiol. 34 , 78, (1988)

Medium m-CP, designed for the isolation of Clostridium perfringens from water samples, contains indoxyl beta-D-glucoside, an expensive chemical that is present at a high concentration in this medium. ...

[Determination of indican in Polygonum tinctorium ait. in various growth periods].

Zhong Yao Tong Bao 13(11) , 11-3, 61-2, (1988)

Distribution, diversity, and seasonality of waterborne salmonellae in a rural watershed.

Appl. Environ. Microbiol. 75(5) , 1248-55, (2009)

Salmonella outbreaks from contaminated water and nonanimal foods (e.g., produce) are increasingly reported. To address the environment as a potential source of pathogenic Salmonella, we investigated l...

 Synonyms

Indikan
Plant indican
Indican
Indole, 3- (β-D-glucopyranosyloxy)-
3-Indolyl-b-D-glucopyranoside
3-Indole-D-glucoside Hydrate
Indoxyl-D-glucoside Hydrate
Indoxyl β-D-glucoside
1H-Indol-3-yl β-D-glucopyranoside
1H-Indol-3-yl β-glucopyranoside
Indoxyl-b-D-glucoside
3-Indolyl-D-glucoside Hydrate
Indoxyl-β-D-glucoside
Indican Hydrate
Uroxanthin
3-Indoxyl-beta-D-glucopyranoside
3-Indoxyl-D-glucoside Hydrate
3-(b-Glucosido)indole
1H-Indol-3-yl-b-D-glucopyranoside
MFCD00047169
Indole, 3-(β-D-glucopyranosyloxy)-
3-Indoxyl-β-D-glucopyranoside
β-D-Glucopyranoside, 1H-indol-3-yl
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Price: ¥550/10 mM * 1 mL in DMSO

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