SNAP-94847 hydrochloride

Modify Date: 2024-01-06 23:24:55

SNAP-94847 hydrochloride Structure
SNAP-94847 hydrochloride structure
Common Name SNAP-94847 hydrochloride
CAS Number 487051-12-7 Molecular Weight 515.03400
Density N/A Boiling Point N/A
Molecular Formula C29H33ClF2N2O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS09
GHS09
Signal Word Warning

 Use of SNAP-94847 hydrochloride


SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCH1) antagonist with antidepressant-like activity, it differentiates from classic anxiolytic and antidepressant drugs.SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.SNAP 94847 is a high affinity antagonist (pA2 = 7.81) of MCH-evoked inositol phosphate formation[1].

 Names

Name N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylph enyl)-2-methylpropanamide hydrochloride (1:1)
Synonym More Synonyms

 SNAP-94847 hydrochloride Biological Activity

Description SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCH1) antagonist with antidepressant-like activity, it differentiates from classic anxiolytic and antidepressant drugs.SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.SNAP 94847 is a high affinity antagonist (pA2 = 7.81) of MCH-evoked inositol phosphate formation[1].
Related Catalog
References

[1]. David DJ, et al. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. Epub 2007 Jan 19.

 Chemical & Physical Properties

Molecular Formula C29H33ClF2N2O2
Molecular Weight 515.03400
Exact Mass 514.22000
PSA 45.06000
LogP 8.42900

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
RIDADR UN 3077 9 / PGIII

 Synonyms

BW 723C86 hydrochloride
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