Rosabulin

Modify Date: 2024-01-10 10:59:22

Rosabulin structure	Common Name	Rosabulin
	CAS Number	501948-05-6	Molecular Weight	400.45300
	Density	1.34	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₆N₄O₂S	Melting Point	233ºC
	MSDS	N/A	Flash Point	N/A

Use of Rosabulin

Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.

Name	2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide
Synonym	More Synonyms

Description	Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer
In Vitro	Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein (Pgp), including lines insensitive to Taxol, Vincristine, and Adriamycin in which Pgp activity is a major contributor to the MDR phenotype[1].
In Vivo	Rosabulin has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].
References	[1]. Keizo Koya, et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Proc Amer Assoc Cancer Res, Volume 45, 2004

Density	1.34
Melting Point	233ºC
Molecular Formula	C₂₂H₁₆N₄O₂S
Molecular Weight	400.45300
Exact Mass	400.09900
PSA	115.50000
LogP	4.06108
Index of Refraction	1.7
Storage condition	2-8℃

HS Code	2934999090

3-Methylisothia...

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Oxalyl chloride

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4-(indolizin-3-...

CAS#:501948-43-2

~78%

Rosabulin

CAS#:501948-05-6

Literature: SBR Pharmaceuticals Corp. Patent: US2003/153759 A1, 2003 ;

p-Tolunitrile

CAS#:104-85-8

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

4-(4-pyridin-2-...

CAS#:501948-45-4

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

4-(indolizin-3-...

CAS#:501948-43-2

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

4-(indolizine-3...

CAS#:501948-42-1

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

P-CYANOACETOPHENONE

CAS#:1443-80-7

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

2-picoline

CAS#:109-06-8

Rosabulin

CAS#:501948-05-6

Literature: Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

UNII-6Z674O12T6

Rosabulin

I01-9450

STA-5312

Rosabulin

Use of Rosabulin

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Rosabulin Biological Activity

Chemical & Physical Properties

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