Polyphyllin D

Modify Date: 2024-01-02 13:18:19

Polyphyllin D structure	Common Name	Polyphyllin D
	CAS Number	50773-41-6	Molecular Weight	855.017
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₄H₇₀O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Polyphyllin D

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

Name	Polyphyllin I
Synonym	More Synonyms

Description	Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1 Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> MAPK/ERK Pathway >> JNK
Target	JNK signaling[2] PDK1/Akt/mTOR signaling[3]
References	[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33. [2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486. [3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₄H₇₀O₁₆
Molecular Weight	855.017
Exact Mass	854.466370
PSA	235.68000
LogP	7.12
Index of Refraction	1.618

HS Code	29389090

Precursor 1
CAS#:122089-71-8 2,3,4-tri-O-ace...
DownStream 3
CAS#:14144-06-0 Diosgenin glucoside CAS#:19057-67-1 Prosapogenin A CAS#:512-04-9 Diosgenin

β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1->4)-O-[6-deoxy-α-L-mannopyranosyl-(1->2)]-

(3β,25R)-Spirost-5-en-3-yl α-L-arabinofuranosyl-(1->4)-[6-deoxy-α-L-mannopyranosyl-(1->2)]-β-D-glucopyranoside

Chonglou saponin I

Polyphyllin A

Polyphyllin Ⅰ

Polyphyllin D

Use of Polyphyllin D

Names

Polyphyllin D Biological Activity

Chemical & Physical Properties

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Synthetic Route

Precursor & DownStream

Synonyms