Verminoside

Modify Date: 2024-01-04 12:13:19

Verminoside structure	Common Name	Verminoside
	CAS Number	50932-19-9	Molecular Weight	492.473
	Density	1.6±0.1 g/cm3	Boiling Point	739.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₈O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	253.2±26.4 °C

Use of Verminoside

Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins[1][2][3].

Name	(1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymeth yl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6 -yl (2E)-3-(3,4-dihydroxyphenyl)acrylate
Synonym	More Synonyms

Description	Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP-1
In Vitro	Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages[1]. Western Blot Analysis[1] Cell Line: J774.A1 macrophages Concentration: 0.01 mM, 0.1 mM or 1 mM Incubation Time: 25 hours Result: Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.
References	[1]. Picerno P, et al. Anti-inflammatory activity of verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J Nat Prod. 2005 Nov;68(11):1610-4. [2]. Boniface PK, et al. RP-HPLC-DAD method for the identification of two potential antioxidant agents namely verminoside and 1-O-(E)-caffeoyl-β-gentiobiose from Spathodea campanulata leaves. Nat Prod Res. 2015;29(7):676-80. [3]. Santoro A, et al. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins. Toxicol Lett. 2008 May 5;178(2):71-6.

Density	1.6±0.1 g/cm3
Boiling Point	739.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₈O₁₃
Molecular Weight	492.473
Flash Point	253.2±26.4 °C
Exact Mass	492.163147
PSA	208.13000
LogP	-1.81
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.671

picroside-1

PicrosideI

2-Propenoic acid, 3-phenyl-, (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester, (2E)-

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-

2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester, (2E)-

6'-O-trans-cinnamoylcatalpol

(1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-β-D-glucopyranoside

picrosides I

Picroside I

(1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl (2E)-3-(3,4-dihydroxyphenyl)acrylate

(1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl (2E)-3-phenylacrylate

Verminoside

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Verminoside
Price: Click To Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Verminoside
Price: ￥3500.0/5mg
Purity: 97.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Verminoside
Price: ￥4800.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

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Verminoside

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