Tiapride

Modify Date: 2024-01-02 13:47:33

Tiapride structure	Common Name	Tiapride
	CAS Number	51012-32-9	Molecular Weight	328.42700
	Density	1.15 g/cm3	Boiling Point	498.1ºC at 760 mmHg
	Molecular Formula	C₁₅H₂₄N₂O₄S	Melting Point	120ºC
	MSDS	USA	Flash Point	255.1ºC

Use of Tiapride

Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. The IC50 values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively[1].

Name	Tiapride hydrochloride
Synonym	More Synonyms

Description	Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. The IC50 values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor:110-320 nM (IC50) D3 Receptor:180 nM (IC50)
References	[1]. D H Peters, et al. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome. Drugs. 1994 Jun;47(6):1010-32. [2]. T Arima, et al. Comparison of effects of tiapride and sulpiride on D-1, D-2, D-3 and D-4 subtypes of dopamine receptors in rat striatal and bovine caudate nucleus membranes. Jpn J Pharmacol. 1986 Jul;41(3):419-23.

Density	1.15 g/cm3
Boiling Point	498.1ºC at 760 mmHg
Melting Point	120ºC
Molecular Formula	C₁₅H₂₄N₂O₄S
Molecular Weight	328.42700
Flash Point	255.1ºC
Exact Mass	328.14600
PSA	87.58000
LogP	2.82590
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV4203700

CHEMICAL NAME :: Benzamide, N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl )-

CAS REGISTRY NUMBER :: 51012-32-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H24-N2-O4-S

MOLECULAR WEIGHT :: 328.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1197 mg/kg

SEX/DURATION :: female 38 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 30,231,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 850 mg/kg

SEX/DURATION :: female 27 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 30,231,1975

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CV4203800
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride

N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide

EINECS 256-907-9

N-(2-(Diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamide

MFCD00242730

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Tiapride

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