51012-32-9

51012-32-9 structure

Name: Tiapride
Chemical Name: Tiapride hydrochloride
CAS Number: 51012-32-9
Molecular Formula: C₁₅H₂₄N₂O₄S
Molecular Weight: 328.42700
Catalog: API Nervous system medication Antipsychotic
Create Date: 2018-08-16 14:55:44
Modify Date: 2024-01-02 13:47:33
Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. The IC50 values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively[1].

Name	Tiapride hydrochloride
Synonyms	N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide EINECS 256-907-9 N-(2-(Diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamide MFCD00242730

Description	Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. The IC50 values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor:110-320 nM (IC50) D3 Receptor:180 nM (IC50)
References	[1]. D H Peters, et al. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome. Drugs. 1994 Jun;47(6):1010-32. [2]. T Arima, et al. Comparison of effects of tiapride and sulpiride on D-1, D-2, D-3 and D-4 subtypes of dopamine receptors in rat striatal and bovine caudate nucleus membranes. Jpn J Pharmacol. 1986 Jul;41(3):419-23.

CHEMICAL NAME :: Benzamide, N-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl )-

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 30,231,1975

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 30,231,1975

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CV4203800
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%