Euphol
Modify Date: 2024-01-02 18:13:05
Euphol structure
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Common Name | Euphol | ||
|---|---|---|---|---|
| CAS Number | 514-47-6 | Molecular Weight | 426.717 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 498.9±44.0 °C at 760 mmHg | |
| Molecular Formula | C30H50O | Melting Point | 116-117ºC | |
| MSDS | N/A | Flash Point | 221.1±20.7 °C | |
Use of EupholEuphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1]. |
| Name | 5.α.-Eupha-8,24-dien-3.β.-ol |
|---|---|
| Synonym | More Synonyms |
| Description | Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1]. |
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| Related Catalog | |
| Target |
IC50: 315 nM (monoacylglycerol lipase activity)[1] |
| In Vitro | Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively[2]. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins[2]. Cell Proliferation Assay[2] Cell Line: T47D cells Concentration: 0.01, 0.03, 0.1 and 0.3 mM Incubation Time: 24, 48 and 72 hours Result: Decreased the percentage of viable cells. Western Blot Analysis[2] Cell Line: T47D cells Concentration: 0.03 mM Incubation Time: 48 and 72 hours Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 498.9±44.0 °C at 760 mmHg |
| Melting Point | 116-117ºC |
| Molecular Formula | C30H50O |
| Molecular Weight | 426.717 |
| Flash Point | 221.1±20.7 °C |
| Exact Mass | 426.386169 |
| PSA | 20.23000 |
| LogP | 11.00 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.530 |
| Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| 13α,14β,17βH-Lanosta-8,24-dien-3β-ol (8CI) |
| Euphadienol |
| (3β,13α,14β,17α)-Lanosta-8,24-dien-3-ol |
| 5α-Eupha-8,24-dien-3β-ol |
| Euphol, Euphadienol |
| euphol |
| Lanosta-8,24-dien-3-ol, (3β,13α,14β,17α)- |