Cycloguanil

Modify Date: 2024-01-09 23:39:03

Cycloguanil Structure
Cycloguanil structure
Common Name Cycloguanil
CAS Number 516-21-2 Molecular Weight 251.71500
Density 1.4g/cm3 Boiling Point 400.7ºC at 760mmHg
Molecular Formula C11H14ClN5 Melting Point N/A
MSDS N/A Flash Point 196.1ºC

 Use of Cycloguanil


Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

 Names

Name 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
Synonym More Synonyms

 Cycloguanil Biological Activity

Description Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Related Catalog
References

[1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

 Chemical & Physical Properties

Density 1.4g/cm3
Boiling Point 400.7ºC at 760mmHg
Molecular Formula C11H14ClN5
Molecular Weight 251.71500
Flash Point 196.1ºC
Exact Mass 251.09400
PSA 75.00000
LogP 2.86690

 Safety Information

HS Code 2933699090

 Synthetic Route

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Cycloguanil Structure

Cycloguanil

CAS#:516-21-2

Literature: Loo Journal of the American Chemical Society, 1954 , vol. 76, p. 5096,5098 Full Text Show Details Bami; Modest; Levine Journal of Organic Chemistry, 1956 , vol. 21, p. 14,19 Full Text Show Details Carrington et al. Journal of the Chemical Society, 1954 , p. 1017,1026

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Cycloguanil Structure

Cycloguanil

CAS#:516-21-2

Literature: Bami Journal of Scientific and Industrial Research, 1955 , vol. 14 C, p. 231,234 Full Text Show Details Basu; Sen Journal of Scientific and Industrial Research, 1952 , vol. 11 B, p. 312 Full Text Show Details Modest Journal of Organic Chemistry, 1956 , vol. 21, p. 1,12

 Customs

HS Code 2933699090
Summary 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

 Synonyms

Cycloguanyl
Cycloguanil
1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine
Chlorcycloguanil
WR 5473
Chlorguanide triazine
1-(4-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine
1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine
1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin