ESI 05

Modify Date: 2024-01-11 20:18:50

ESI 05 Structure
ESI 05 structure
Common Name ESI 05
CAS Number 5184-64-5 Molecular Weight 274.37800
Density 1.129g/cm3 Boiling Point 426.7ºC at 760mmHg
Molecular Formula C16H18O2S Melting Point N/A
MSDS N/A Flash Point 250ºC

 Use of ESI 05


ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].

 Names

Name 1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene
Synonym More Synonyms

 ESI 05 Biological Activity

Description ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].
Related Catalog
Target

IC50: 0.4 µM (EPAC2)[1]

References

[1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.

 Chemical & Physical Properties

Density 1.129g/cm3
Boiling Point 426.7ºC at 760mmHg
Molecular Formula C16H18O2S
Molecular Weight 274.37800
Flash Point 250ºC
Exact Mass 274.10300
PSA 42.52000
LogP 4.83380
Index of Refraction 1.562

 Synthetic Route

 Synonyms

mesityl(4-methylphenyl) sulfone
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