Hydroxy-PEG2-CH2COOH

Modify Date: 2024-01-20 09:53:33

Hydroxy-PEG2-CH2COOH Structure
Hydroxy-PEG2-CH2COOH structure
Common Name Hydroxy-PEG2-CH2COOH
CAS Number 51951-04-3 Molecular Weight 164.156
Density 1.2±0.0 g/cm3 Boiling Point 343.4±0.0 °C at 760 mmHg
Molecular Formula C6H12O5 Melting Point N/A
MSDS N/A Flash Point 144.3±0.0 °C

 Use of Hydroxy-PEG2-CH2COOH


Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name [2-(2-Hydroxyethoxy)ethoxy]acetic acid
Synonym More Synonyms

 Hydroxy-PEG2-CH2COOH Biological Activity

Description Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.2±0.0 g/cm3
Boiling Point 343.4±0.0 °C at 760 mmHg
Molecular Formula C6H12O5
Molecular Weight 164.156
Flash Point 144.3±0.0 °C
Exact Mass 164.068466
LogP -1.73
Vapour Pressure 0.0±0.0 mmHg at 25°C
Index of Refraction 1.462

 Synonyms

[2-(2-Hydroxyethoxy)ethoxy]acetic acid
MFCD20640451
Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-
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