bronopol

Modify Date: 2025-08-20 16:43:49

bronopol Structure
bronopol structure
 Common Name bronopol
CAS Number 52-51-7 Molecular Weight 199.988
Density 2.0±0.1 g/cm3 Boiling Point 358.0±42.0 °C at 760 mmHg
Molecular Formula C3H6BrNO4 Melting Point 130-133 °C(lit.)
MSDS Chinese USA Flash Point 170.3±27.9 °C
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09		 Signal Word Danger

 Use of bronopol


Bronopol is an antimicrobial, with low mammalian toxicity (at in-use levels) and high activity against bacteria (especially the troublesome Gram-negative species).

 Names

Name bronopol
Synonym More Synonyms

 bronopol Biological Activity

Description Bronopol is an antimicrobial, with low mammalian toxicity (at in-use levels) and high activity against bacteria (especially the troublesome Gram-negative species).
Related Catalog

 Chemical & Physical Properties

Density 2.0±0.1 g/cm3
Boiling Point 358.0±42.0 °C at 760 mmHg
Melting Point 130-133 °C(lit.)
Molecular Formula C3H6BrNO4
Molecular Weight 199.988
Flash Point 170.3±27.9 °C
Exact Mass 198.948013
PSA 86.28000
LogP 1.72
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.575
InChIKey LVDKZNITIUWNER-UHFFFAOYSA-N
SMILES O=[N+]([O-])C(Br)(CO)CO
Stability Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture.
Water Solubility 25 g/100 mL (22 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TY3385000
CHEMICAL NAME :
1,3-Propanediol, 2-bromo-2-nitro-
CAS REGISTRY NUMBER :
52-51-7
BEILSTEIN REFERENCE NO. :
1705868
LAST UPDATED :
199701
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C3-H6-Br-N-O4
MOLECULAR WEIGHT :
200.01
WISWESSER LINE NOTATION :
WNXE1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(4),47,1980
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(4),47,1980
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,30,1976
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,103,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A542,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,1029,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,103,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 11(1),73,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
116 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,30,1976 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 3(3),139,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1235 No. of Facilities: 117 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 5176 (estimated) No. of Female Employees: 4904 (estimated)

 Safety Information

Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H302 + H312-H315-H318-H335-H410
Precautionary Statements P273-P280-P302 + P352 + P312-P305 + P351 + P338 + P310-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R21/22;R37/38;R41;R50
Safety Phrases S26-S37/39-S61
RIDADR UN 3241 4.1/PG 3
WGK Germany 2
RTECS TY3385000
Packaging Group III
Hazard Class 4.1
HS Code 2905590030

 Synthetic Route

Formaldehyde structure

Formaldehyde

CAS#:50-00-0

nitromethane structure

nitromethane

CAS#:75-52-5

Tribromonitromethane structure

Tribromonitromethane

CAS#:464-10-8

~74%

bronopol Structure

bronopol

CAS#:52-51-7

Literature: BROMINE COMPOUNDS LTD. Patent: WO2009/107133 A1, 2009 ; Location in patent: Page/Page column 22-24 ;
2-(Hydroxymethyl)-2-nitropropan-1,3-diol structure

2-(Hydroxymethy...

CAS#:126-11-4

~%

bronopol Structure

bronopol

CAS#:52-51-7

Literature: Trenel; Wilkendorf Chemische Berichte, 1924 , vol. 57, p. 2129
Formaldehyde structure

Formaldehyde

CAS#:50-00-0

~%

bronopol Structure

bronopol

CAS#:52-51-7

Literature: Urbanski et al. Roczniki Chemii, 1957 , vol. 31, p. 93,96 Chem.Abstr., 1957 , p. 14717
Formaldehyde structure

Formaldehyde

CAS#:50-00-0

Bromonitromethane structure

Bromonitromethane

CAS#:563-70-2

~%

bronopol Structure

bronopol

CAS#:52-51-7

Literature: Maas Chem. Zentralbl., 1899 , vol. 70, # I p. 179 Full Text Show Details Henry Recueil des Travaux Chimiques des Pays-Bas, 1897 , vol. 16, p. 252 Chem. Zentralbl., 1898 , vol. 69, # I p. 192
2-(Hydroxymethyl)-2-nitropropan-1,3-diol structure

2-(Hydroxymethy...

CAS#:126-11-4

~%

bronopol Structure

bronopol

CAS#:52-51-7

Tribromonitromethane structure

Tribromonitromethane

CAS#:464-10-8

Literature: Trenel; Wilkendorf Chemische Berichte, 1924 , vol. 57, p. 2129

 Customs

HS Code 2905590030

 Articles27

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 bronopolBioassay

View more

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
Total 282, Current Page 1 of 29
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 Synonyms

UN 3241
MFCD00007390
UNII-6PU1E16C9W
bronopol
EINECS 200-143-0
2-Bromo-2-nitropropane-1,3-diol (Bronopol)
2-Bromo-2-nitro-1,3-propanediol
b-Bromo-b-nitrotrimethyleneglycol
2-bromo-2-nitropropane-1,3-diol
2-Brom-2-nitropropan-1,3-diol
2-Bromo-2-nitro-1,3-propanediol,BNPD,BNPK
4-01-00-02501 (Beilstein Handbook Reference)
WNXE1Q1Q
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1251131-77-7
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1253575-74-4
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2580224-50-4
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1250667-45-8
Chemsrc provides bronopol(CAS#:52-51-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of bronopol are included as well.>> amp version: bronopol

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