Hesperidin

Modify Date: 2024-01-02 12:26:56

Hesperidin structure	Common Name	Hesperidin
	CAS Number	520-26-3	Molecular Weight	610.561
	Density	1.7±0.1 g/cm3	Boiling Point	930.1±65.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₃₄O₁₅	Melting Point	250-255 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	305.5±27.8 °C

Use of Hesperidin

Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]

Name	hesperidin
Synonym	More Synonyms

Description	Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Flavonoids Research Areas >> Cancer
References	[1]. Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493. [2]. Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97. [3]. Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682. [4]. Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Natural Products >> Flavonoids

Research Areas >> Cancer

References

[1]. Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493.

[2]. Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97.

[3]. Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682.

[4]. Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.

Density	1.7±0.1 g/cm3
Boiling Point	930.1±65.0 °C at 760 mmHg
Melting Point	250-255 °C (dec.)(lit.)
Molecular Formula	C₂₈H₃₄O₁₅
Molecular Weight	610.561
Flash Point	305.5±27.8 °C
Exact Mass	610.189758
PSA	234.29000
LogP	1.78
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.695

Hesperidin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MK6650000

CHEMICAL NAME :: Hesperidin

CAS REGISTRY NUMBER :: 520-26-3

BEILSTEIN REFERENCE NO. :: 0075140

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C28-H34-O15

MOLECULAR WEIGHT :: 610.62

WISWESSER LINE NOTATION :: T66 BO EVT&J CR CQ DO1& GQ IO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1 GLUCO RHAMNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84694 No. of Facilities: 156 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 8654 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MK6650000

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Literature: Belboukhari, Nasser; Cheriti, Abdelkrim; Roussel, Christian; Vanthuyne, Nicolas Natural Product Research, 2010 , vol. 24, # 7 p. 669 - 681

Precursor 4
CAS#:161713-86-6 alpha-Glucosyl ... CAS#:64-17-5 Ethanol CAS#:50376-44-8 3,2',6'-trihydr... CAS#:64726-90-5 hesperetin 7-O-...
DownStream 6
CAS#:537-73-5 Isoferulic acid CAS#:520-27-4 Diosmin CAS#:520-33-2 Hesperetin CAS#:1356391-89-3 4-methylumbelli...
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Bio-refinery of orange peels waste: a new concept based on integrated green and solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin.

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The purpose of this study is to investigate the changes occured on phenolic compounds between two Malaysian varieties of pummelo fruit juice: Ledang (PO55) and Tambun (PO52) post-enzymatic clarificati...

Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.

Food Chem. Toxicol. 74 , 51-9, (2014)

D-galactose, a reducing sugar, induces oxidative stress resulting in alteration in mitochondrial dynamics and apoptosis of neurons. Curcumin and hesperidin are antioxidants possessing multimodal funct...

usafcf-3

Hesperetin 7-rhamnoglucoside,Hesperitin-7-rutinoside

VITAMIN P

Hespeidin

Hespiridin

Hesperiden

Neobiletin

cirantin

MFCD00075663

Hesperetin7-rutinoside

Cirontin

Hesperidoside

Hesperetin7-rhamnoglucoside

Hesperidin

EINECS 208-288-1

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China
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China
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China
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Purity: 99.0%
Delivery: Inquiry
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