Angelicin structure
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Common Name | Angelicin | ||
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CAS Number | 523-50-2 | Molecular Weight | 186.163 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 362.6±27.0 °C at 760 mmHg | |
Molecular Formula | C11H6O3 | Melting Point | 132-134ºC | |
MSDS | Chinese USA | Flash Point | 173.1±23.7 °C | |
Symbol |
GHS07, GHS08 |
Signal Word | Warning |
Use of AngelicinAngelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells [2]. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways [3].In vivo: |
Name | angelicin |
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Synonym | More Synonyms |
Description | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells [2]. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways [3].In vivo: |
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Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 362.6±27.0 °C at 760 mmHg |
Melting Point | 132-134ºC |
Molecular Formula | C11H6O3 |
Molecular Weight | 186.163 |
Flash Point | 173.1±23.7 °C |
Exact Mass | 186.031693 |
PSA | 43.35000 |
LogP | 2.01 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.667 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS07, GHS08 |
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Signal Word | Warning |
Hazard Statements | H302 + H312 + H332-H315-H319-H335-H351 |
Precautionary Statements | P261-P280-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R20/21/22;R36/37/38;R40 |
Safety Phrases | S26-S36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | LV0940000 |
HS Code | 2932999099 |
HS Code | 2932999099 |
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Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography.
Food Chem. 186 , 133-8, (2015) An efficient strategy, based on bioassay-guided fractionation, high-performance liquid chromatography (HPLC), and high-performance counter-current chromatography (HPCCC), was established to purify and... |
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Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures
Food Chem. Toxicol. 68 , 257-66, (2014) • The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica arch... |
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F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetales.
PLoS ONE 7(2) , e30114, (2012) Two classes of F(420)-dependent reductases (FDR-A and FDR-B) that can reduce aflatoxins and thereby degrade them have previously been isolated from Mycobacterium smegmatis. One class, the FDR-A enzyme... |
2H-Furo[2,3-h][1]benzopyran-2-one |
4-Hydroxy-5-benzofuranacrylic acid γ-lactone |
Furo[2,3-h]benzopyran-2-one |
EINECS 201-480-6 |
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran,2H-Furo[2,3-h]-1-benzopyran-2-one |
ISOPSORALENE |
Isopsoralen |
ANGELICINE |
angecin |
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran 2H-Furo[2,3-h]-1-benzopyran-2-one |
T B566 EO LVOJ |
MFCD00064930 |
2H-Furo[2,3-h]chromen-2-one |
2H-Furo[2,3-h]-1-benzopyran-2-one |
isopsoralin |
Angelicin |
ISOBERGAPTEN |