(R)-DPN

Modify Date: 2024-01-31 21:23:51

(R)-DPN structure	Common Name	(R)-DPN
	CAS Number	524047-78-7	Molecular Weight	239.269
	Density	1.3±0.1 g/cm3	Boiling Point	449.4±35.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	225.6±25.9 °C

Use of (R)-DPN

R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].

Name	(r)-dpn
Synonym	More Synonyms

Description	R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
Target	ERα:2.9 nM (EC50) ERβ:0.8 nM (EC50)
References	[1]. Carroll VM, et al. Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J Med Chem. 2012 Jan 12;55(1):528-37.

Density	1.3±0.1 g/cm3
Boiling Point	449.4±35.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₃NO₂
Molecular Weight	239.269
Flash Point	225.6±25.9 °C
Exact Mass	239.094635
PSA	64.25000
LogP	2.06
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.640

(2R)-2,3-Bis(4-hydroxyphenyl)propanenitrile

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Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-, (αR)-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: （R）-DPN
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
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(R)-DPN

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