524047-78-7

524047-78-7 structure

Name: (R)-DPN
Chemical Name: (r)-dpn
CAS Number: 524047-78-7
Molecular Formula: C₁₅H₁₃NO₂
Molecular Weight: 239.269
Catalog: Research Areas Endocrinology
Create Date: 2017-09-25 16:40:06
Modify Date: 2024-01-31 21:23:51
R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].

Name	(r)-dpn
Synonyms	(2R)-2,3-Bis(4-hydroxyphenyl)propanenitrile DMAB-anabaseine dihydrochloride Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-, (αR)-

Description	R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
Target	ERα:2.9 nM (EC50) ERβ:0.8 nM (EC50)
References	[1]. Carroll VM, et al. Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J Med Chem. 2012 Jan 12;55(1):528-37.