L-(+)-Abrine

Modify Date: 2024-01-01 20:06:02

L-(+)-Abrine Structure
L-(+)-Abrine structure
 Common Name L-(+)-Abrine
CAS Number 526-31-8 Molecular Weight 218.252
Density 1.3±0.1 g/cm3 Boiling Point 439.1±35.0 °C at 760 mmHg
Molecular Formula C12H14N2O2 Melting Point >300 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 219.4±25.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of L-(+)-Abrine


L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.

 Names

Name Nα-methyl-L-tryptophan
Synonym More Synonyms

 L-(+)-Abrine Biological Activity

Description L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.
Related Catalog
In Vitro L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine[1].
In Vivo Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment[2].
Animal Admin Rats[2] Twenty male Wistar rats, approximately 6-7 weeks of age and weighing approximately 175-200 g upon receipt, are used. A total of 12 rats are dosed intramuscularly with L-(+)-Abrine at 0.63, 3.13, and 5 times the expected Abrin LD50 of 20 μg/kg. Although no toxin is used here, the concentration of the biomarker is increased by a factor of 4 to estimate an equivalent level of toxin, assuming that Labrine is present in rosary peas at a concentration four times greater that the toxin abrin. A total of 12 rats are dosed intramuscularly with L-(+)-Abrine: four at approximately 50 μg/kg body weight (bw), four at 250 μg/kg bw, and four at 400 μg/kg bw. Four control rats are dosed with water, which is the vehicle for all dosing experiments. Another four rats are dosed intraperitoneally with 20,000 μg/kg L-tryptophan to verify that endogenous L-tryptophan is not metabolized to L-(+)-Abrine[2].
References

[1]. Cho H, et al. A portable and chromogenic enzyme-based sensor for detection of abrin poisoning. Biosens Bioelectron. 2014 Apr 15;54:667-73.

[2]. Johnson RC, et al. Quantification of L-abrine in human and rat urine: a biomarker for the toxin abrin. J Anal Toxicol. 2009 Mar;33(2):77-84.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 439.1±35.0 °C at 760 mmHg
Melting Point >300 °C (dec.)(lit.)
Molecular Formula C12H14N2O2
Molecular Weight 218.252
Flash Point 219.4±25.9 °C
Exact Mass 218.105530
PSA 65.12000
LogP 1.18
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.649

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles3

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 Synonyms

a-Methylamino-b-(3-indole)propionic Acid
N-ME-TRYPTOPHAN
L-N-Methyltryptophan
N-Methyl-L-tryptophan
L-Tryptophan, N-methyl-
H-METRP-OH
L-Abrine
Abrine
L-2-methyltryptophan
EINECS 208-388-5
ABRINE,L
N-methyl-tryptophan
N-α-Methyl-L-trytophan
N(α)-methyl-L-tryptophan
N(α)-methyl-L-tryptophan zwitterion
N(alpha)-methyl-L-tryptophan
MFCD00005645
Nα-Methyl-L-tryptophan
N-ME-TRP-OH HCL
N-ME-TRP-OH
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