Caulophyllogenin

Modify Date: 2024-01-03 10:08:15

Caulophyllogenin structure	Common Name	Caulophyllogenin
	CAS Number	52936-64-8	Molecular Weight	488.69900
	Density	1.19g/cm3	Boiling Point	621.5ºC at 760mmHg
	Molecular Formula	C₃₀H₄₈O₅	Melting Point	>300ºC (dec.)
	MSDS	N/A	Flash Point	343.7ºC

Use of Caulophyllogenin

Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation[1][2].

Name	(4aR,5R,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-5,10-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Synonym	More Synonyms

Description	Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	PPARγ:12.6 μM (EC50)
References	[1]. Montanari R, et, al. Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin. Sci Rep. 2016 Jun 10; 6:27658. [2]. Zhang Y, et, al. Studies on cytotoxic triterpene saponins from the leaves of Aralia elata. Food Chem. 2013 May 1;138(1):208-13.

Density	1.19g/cm3
Boiling Point	621.5ºC at 760mmHg
Melting Point	>300ºC (dec.)
Molecular Formula	C₃₀H₄₈O₅
Molecular Weight	488.69900
Flash Point	343.7ºC
Exact Mass	488.35000
PSA	97.99000
LogP	5.17680
Index of Refraction	1.58
Storage condition	2-8°C