Ginsenoside F1

Modify Date: 2024-01-02 23:45:15

Ginsenoside F1 Structure
Ginsenoside F1 structure
 Common Name Ginsenoside F1
CAS Number 53963-43-2 Molecular Weight 638.872
Density 1.2±0.1 g/cm3 Boiling Point 751.7±60.0 °C at 760 mmHg
Molecular Formula C36H62O9 Melting Point N/A
MSDS Chinese USA Flash Point 408.4±32.9 °C

 Use of Ginsenoside F1


Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.

 Names

Name ginsenoside F1
Synonym More Synonyms

 Ginsenoside F1 Biological Activity

Description Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.
Related Catalog
Target

CYP3A4

In Vitro Ginsenoside F1 has been shown to flaunt anticancer, anti-aging, and antioxidant effects and has demonstrated competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity. The cell viabilities are 68% at the highest concentration of ginsenoside F1 (200μM) in MTT assays[1].
In Vivo ApoE-/- mice are fed a high fat diet and orally treated with Ginsenoside F1 (50 mg/kg/day) for 8 weeks. Ginsenoside F1 treated mice significantly reduce the lesion size compared with model group mice[2].
Kinase Assay Glycosylation ability is assayed with overexpressed BSGT1 enzyme and F1. The reaction mixtures contain 100 μL of 0.5 mM F1 and 100 μL of 2.5 mM UDP-glucose and 800 μL of purified enzyme (final concentration at 0.1 mg/mL) (pH 7.0). The mixtures are incubated at 30°C for 24 h. Moreover, three groups of controls are incubated under the same conditions: (1) control 1 (C1) consists of Ginsenoside F1 with BSGT1; (2) control 2 (C2) consists of BSGT1 with UDP-glucose; and (3) control 3 (C3) consists of Ginsenoside F1 with UDP-glucose[1].
Cell Assay B16BL6 cells are cultured in Dulbecco's modified Eagles medium supplemented with 10% fetal bovine serum and 1% Penicillin-Streptomycin at 37°C in a humidified 95% air/5% CO2 atmosphere. Cell viability is determined for Ginsenoside F1 and metabolite 1 using MTT conversion to formazan. Cells are seeded at a density of 1×105 cells/well in a 96-well plate, cultured for 24 h, and treated with various concentrations from 1 μM to 200 μM of Ginsenoside F1 and metabolite 1 for 5 d. Finally, 10 μL of MTT (5 mg/mL in PBS) is added to each well. Cells are incubated at 37°C for 3 h, and then DMSO (100 μL) is added to dissolve the formazan crystals. The absorbance is measured at 570 nm with the reference wavelength of 630 nm using an ELISA reader[1].
Animal Admin Mice[2] Six-week-old (17±1 g) male C57BL/6 mice and ApoE-/- mice with a C57BL/6 background are maintained in a temperature-controlled facility (temperature: 22±1°C; humidity: 60%) with a 14 h light/10 h dark cycle in conventional cages. Forty mice are randomly divided into four experimental groups (n=10/group): (I) C57BL/6 N mice, the control group; (II) ApoE-/- mice group; (III) ApoE-/- mice+ Ginsenoside F1 group; (IV) ApoE-/- mice+Probucol group. All mice are fed with a high fat diet (HFD, 0.3% cholesterol and 20% pork fat) for 8 weeks. Ginsenoside F1 (50 mg/kg/day, i.g.) and Probucol (2 g/kg, i.g.) are dissolved in carboxymethyl cellulose sodium (CMC-Na). Oral administration is given to mice every day for 8 weeks. The control and model groups receive the aseptic 0.5% CMC-Na treatment every day (i.g., 0.1 mL/10g) [2].
References

[1]. Wang DD, et al. Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitromelanogenesis inhibition activity in BL6B16 cells. J Ginseng Res. 2018 Jan;42(1):42-49.

[2]. Qin M, et al. Ginsenoside F1 Ameliorates Endothelial Cell Inflammatory Injury and Prevents Atherosclerosis in Mice through A20-Mediated Suppression of NF-kB Signaling. Front Pharmacol. 2017 Dec 22;8:953.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 751.7±60.0 °C at 760 mmHg
Molecular Formula C36H62O9
Molecular Weight 638.872
Flash Point 408.4±32.9 °C
Exact Mass 638.439392
PSA 160.07000
LogP 3.80
Vapour Pressure 0.0±5.7 mmHg at 25°C
Index of Refraction 1.581

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

β-D-Glucopyranoside, (3β,6α,12β)-3,6,12-trihydroxydammar-24-en-20-yl
Ginsenoside F1
GINSENOSIDEF1
Ginsenoside-F1
(3β,6α,12β)-3,6,12-Trihydroxydammar-24-en-20-yl β-D-glucopyranoside
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Chemsrc provides Ginsenoside F1(CAS#:53963-43-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ginsenoside F1 are included as well.>> amp version: Ginsenoside F1

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