WF-536
Modify Date: 2024-01-10 09:47:33
WF-536 structure
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Common Name | WF-536 | ||
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| CAS Number | 539857-64-2 | Molecular Weight | 277.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H16ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of WF-536WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1]. |
| Name | WF-536 |
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| Description | WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1]. |
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| Related Catalog | |
| In Vitro | WF-536（1、3、10、30、100 μM）抑制 LLC 细胞的侵袭和迁移以及内皮细胞在 Matrigel 上的侵袭、迁移和毛细管样管的形成，在这两种细胞类型下均无细胞毒性或抗增殖作用[1]。 Cell Migration Assay [1] Cell Line: LLC cells, Human umbilical vein endothelial cells Concentration: 1, 3, 10, 30 μM Incubation Time: 6 h (tumor cells), 4 h (endothelial cells) Result: Significantly inhibited LLC-cell migration, with inhibitory rates of 23% and 44% at 10 and 30 μM, respectively. Cell Invasion Assay[1] Cell Line: LLC cells, Human umbilical vein endothelial cells Concentration: 1, 3, 10, 30 μM Incubation Time: 18 h Result: Showed significant and concentration-dependent inhibition of LLC-cell invasion. Cell Proliferation Assay[1] Cell Line: LLC cells, Human umbilical vein endothelial cells Concentration: 1, 30, 100 μM Incubation Time: 24, 48, 72, and 96 h Result: Showed no significant effect at 1-30 μM on the proliferation up to 96 h incubation, although the proliferation was decreased at 100 μM over 48 h. |
| In Vivo | WF-536（口服；0.3-3 mg/kg/天；持续 28 天）抑制小鼠 Lewis 肺癌 (LLC) 转移和 LLC 诱导的血管生成[1]。 Animal Model: C57BL/6 mice (male, 6-week old)[1] Dosage: 0.3, 1, 3 mg/kg Administration: Oral; daily; for 28 days Result: Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg). |
| References |
| Molecular Formula | C14H16ClN3O |
|---|---|
| Molecular Weight | 277.75 |