PFI-90
Modify Date: 2024-01-11 10:56:05
PFI-90 structure
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Common Name | PFI-90 | ||
|---|---|---|---|---|
| CAS Number | 53995-62-3 | Molecular Weight | 214.22300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H10N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PFI-90PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). |
| Name | N'-(pyridin-2-yl)picolinohydrazide |
|---|---|
| Synonym | More Synonyms |
| Description | PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). |
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| Related Catalog | |
| Target |
IC50: 812 nM (RH4); 3200 nM (RH30); 1895 nM (OSA-CL); 1113 nM (TC-32)[1] |
| In Vitro | PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. Western Blot Analysis[1] Cell Line: RH4 and SCMC cells Concentration: 3 μΜ Incubation Time: 24 hours Result: Apoptosis increased in RH4 and SCMC cells. |
| References |
| Molecular Formula | C11H10N4O |
|---|---|
| Molecular Weight | 214.22300 |
| Exact Mass | 214.08500 |
| PSA | 66.91000 |
| LogP | 1.69740 |
| Hazard Codes | Xi |
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| Precursor 0 | |
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| DownStream 1 | |
![3-pyridin-2-yl-[1,2,4]triazolo[4,3-a]pyridine structure](https://image.chemsrc.com/caspic/096/5006-54-2.png)
CAS#:5006-54-2| MFCD27925103 |