Surfen

Modify Date: 2024-05-12 15:01:14

Surfen structure	Common Name	Surfen
	CAS Number	5424-37-3	Molecular Weight	445.34
	Density	N/A	Boiling Point	587.2ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₂Cl₂N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	308.9ºC

Use of Surfen

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

Name	1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
Synonym	More Synonyms

Description	Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	FGFR2:5 μM (IC50) HSV-1
References	[1]. Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.

Boiling Point	587.2ºC at 760 mmHg
Molecular Formula	C₂₁H₂₂Cl₂N₆O
Molecular Weight	445.34
Flash Point	308.9ºC
Exact Mass	408.14700
PSA	118.95000
LogP	6.31860

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS1950300

CHEMICAL NAME :: Urea, 1,3-bis(4-amino-2-methyl-6-quinolyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 5424-37-3

LAST UPDATED :: 198308

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H20-N6-O.2Cl-H

MOLECULAR WEIGHT :: 445.39

WISWESSER LINE NOTATION :: T66 BNJ C1 EZ HMVM- HT66 BNJ C1 EZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952

Aminoquincarbamide dihydrochloride

Aminoquinuride hydrochloride

DC Chemicals Limited
China
Product Name: Surfen hydrate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Urea,N,N'-bis(4-amino-2-methyl-6-quinolinyl)-, hydrochloride (1:2)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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