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5424-37-3

5424-37-3 structure
5424-37-3 structure
  • Name: Surfen
  • Chemical Name: 1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
  • CAS Number: 5424-37-3
  • Molecular Formula: C21H22Cl2N6O
  • Molecular Weight: 445.34
  • Catalog: Signaling Pathways Anti-infection HSV
  • Create Date: 2016-10-21 22:33:03
  • Modify Date: 2024-05-12 15:01:14
  • Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].
Name 1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
Synonyms Aminoquincarbamide dihydrochloride
Aminoquinuride hydrochloride
Description Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].
Related Catalog
Target

FGFR2:5 μM (IC50)

HSV-1

References

[1]. Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.
Boiling Point 587.2ºC at 760 mmHg
Molecular Formula C21H22Cl2N6O
Molecular Weight 445.34
Flash Point 308.9ºC
Exact Mass 408.14700
PSA 118.95000
LogP 6.31860

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS1950300
CHEMICAL NAME :
Urea, 1,3-bis(4-amino-2-methyl-6-quinolyl)-, dihydrochloride
CAS REGISTRY NUMBER :
5424-37-3
LAST UPDATED :
198308
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H20-N6-O.2Cl-H
MOLECULAR WEIGHT :
445.39
WISWESSER LINE NOTATION :
T66 BNJ C1 EZ HMVM- HT66 BNJ C1 EZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
312 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16300 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952

Chemsrc provides CAS#:5424-37-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 5424-37-3 | Chemsrc address: https://www.chemsrc.com/en/baike/1035162.html

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