Deoxycorticosterone-d8

Modify Date: 2024-01-09 11:49:55

Deoxycorticosterone-d8 Structure
Deoxycorticosterone-d8 structure
Common Name Deoxycorticosterone-d8
CAS Number 55487-63-3 Molecular Weight 338.510
Density 1.2±0.1 g/cm3 Boiling Point 488.0±45.0 °C at 760 mmHg
Molecular Formula C21H22D8O3 Melting Point 132-134ºC
MSDS N/A Flash Point 263.0±25.2 °C

 Use of Deoxycorticosterone-d8


Deoxycorticosterone-d8 is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].

 Names

Name 11-Deoxy Corticosterone-d8
Synonym More Synonyms

 Deoxycorticosterone-d8 Biological Activity

Description Deoxycorticosterone-d8 is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. KAGAWA CM, et al. Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science. 1957 Nov 15;126(3281):1015-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 488.0±45.0 °C at 760 mmHg
Melting Point 132-134ºC
Molecular Formula C21H22D8O3
Molecular Weight 338.510
Flash Point 263.0±25.2 °C
Exact Mass 338.269714
PSA 54.37000
LogP 3.41
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.559

 Synonyms

Pregn-4-ene-3,20-dione-2,2,4,6,6,17,21,21-d, 21-hydroxy-
21-Hydroxy(2,2,4,6,6,17,21,21-H)pregn-4-ene-3,20-dione
4-pregnen-21-ol-3,20-dione-2,2,4,6,6,17alpha,21,21-d8