4-Aminobutanoic acid

Modify Date: 2024-01-02 11:55:16

4-Aminobutanoic acid structure	Common Name	4-Aminobutanoic acid
	CAS Number	56-12-2	Molecular Weight	103.120
	Density	1.1±0.1 g/cm3	Boiling Point	248.0±23.0 °C at 760 mmHg
	Molecular Formula	C₄H₉NO₂	Melting Point	195-204ºC
	MSDS	Chinese USA	Flash Point	103.8±22.6 °C

Use of 4-Aminobutanoic acid

γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].

Name	γ-aminobutyric acid
Synonym	More Synonyms

Description	γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Others Research Areas >> Neurological Disease
Target	GABA Receptor[1][2]
References	[1]. Watanabe M, et al. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol. 2002;213:1-47. [2]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91. [3]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2.

Density	1.1±0.1 g/cm3
Boiling Point	248.0±23.0 °C at 760 mmHg
Melting Point	195-204ºC
Molecular Formula	C₄H₉NO₂
Molecular Weight	103.120
Flash Point	103.8±22.6 °C
Exact Mass	103.063332
PSA	63.32000
LogP	-0.64
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.465
Storage condition	Store at RT.
Water Solubility	H2O: 1 M at 20 °C, clear, colorless \| SOLUBLE

4-Aminobutanoic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES6300000

CHEMICAL NAME :: Butyric acid, 4-amino-

CAS REGISTRY NUMBER :: 56-12-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C4-H9-N-O2

MOLECULAR WEIGHT :: 103.14

WISWESSER LINE NOTATION :: Z3VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

REFERENCE :: AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 13,70,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,1901,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 85,463,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4950 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

REFERENCE :: AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 13,70,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 85,463,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2748 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,233,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 47,205,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 13,70,1965 *** REVIEWS *** TOXICOLOGY REVIEW AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 13,70,1965

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	ES6300000
HS Code	29224995

Precursor 9
CAS#:100340-10-1 1,5-dihydrospir... CAS#:21994-40-1 Butanenitrile, ... CAS#:56-86-0 L-glutamic acid CAS#:692-29-5 Succinaldehydic acid
CAS#:57294-38-9 Boc-GABA-OH CAS#:16051-87-9 3-Cyanopropanoi... CAS#:13325-10-5 4-Amino-1-butanol CAS#:616-45-5 2-Pyrrolidinone
CAS#:10137-67-4 Ethyl 3-Cyano P...
DownStream 10
CAS#:107466-55-7 4-[(2-aminobenz... CAS#:10466-75-8 Butanoic acid,4... CAS#:5105-78-2 N-Carbobenzoxy-... CAS#:3130-75-4 4-(1,3-dioxo-1,...
CAS#:50632-83-2 4-[(2,2,2-trifl... CAS#:57078-98-5 4-(2,5-dioxo-2H... CAS#:57294-38-9 Boc-GABA-OH CAS#:141985-40-2 4-[(1,3-dimethy...
CAS#:463-00-3 4-Guanidinobuta... CAS#:13477-53-7 (2S)-4-Amino-2-...

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice.

Toxicol. Appl. Pharmacol. 279(3) , 391-400, (2014)

Methamidophos (MET) is a highly toxic organophosphate (OP) pesticide that is widely used in developing countries. MET has male reproductive effects, including decreased fertility. We evaluated MET eff...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

γ-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABAA receptors in Drosophila.

J. Neurochem. 130(3) , 408-18, (2014)

Drosophila larvae innately show light avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involve...

4-Aminobutanoic acid

MFCD00008226

EINECS 200-258-6

g-Aminobutyric acid

g-Amino-n-butyric Acid

GABA

Butanoic acid, 4-amino-

γ-Amino-n-butyric acid

gamma-aminobutyric acid

4-Aminobutyric acid

GL Biochem (Shanghai) Ltd.
China
Product Name: 4-Aminobutanoic acid
Price: ￥Inquiry/1kg ￥Inquiry/100g
Purity: 99.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Aminobutanoic acid
Price: ￥108.0/100g ￥348.0/500g ￥68.0/100mg
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: γ-Aminobutyric acid (4-Aminobutyric acid)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: γ-Aminobutyric acid (4-Aminobutyric acid)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Aminobutyric acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: γ-aminobutyric acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: Γ-aminobutyric acid 56-12-2
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

Get all suppliers and price by the below link:

4-Aminobutanoic acid suppliers

Price: ￥390/25mg

Reference only. check more 4-Aminobutanoic acid price

4-Aminobutanoic acid

Use of 4-Aminobutanoic acid

Names