Glycine

Modify Date: 2024-01-02 18:00:50

Glycine Structure
Glycine structure
 Common Name Glycine
CAS Number 56-40-6 Molecular Weight 75.067
Density 1.3±0.1 g/cm3 Boiling Point 240.9±23.0 °C at 760 mmHg
Molecular Formula C2H5NO2 Melting Point 240 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 99.5±22.6 °C

 Use of Glycine


Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

 Names

Name glycine
Synonym More Synonyms

 Glycine Biological Activity

Description Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325(6104):529-31.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 240.9±23.0 °C at 760 mmHg
Melting Point 240 °C (dec.)(lit.)
Molecular Formula C2H5NO2
Molecular Weight 75.067
Flash Point 99.5±22.6 °C
Exact Mass 75.032028
PSA 63.32000
LogP -1.03
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.461
Storage condition 2-8°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility 25 g/100 mL (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB7600000
CHEMICAL NAME :
Glycine
CAS REGISTRY NUMBER :
56-40-6
LAST UPDATED :
199710
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C2-H5-N-O2
MOLECULAR WEIGHT :
75.08
WISWESSER LINE NOTATION :
Z1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7930 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle weakness Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45 gm/kg/30D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80389 No. of Facilities: 1797 (estimated) No. of Industries: 17 No. of Occupations: 25 No. of Employees: 25710 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80389 No. of Facilities: 3706 (estimated) No. of Industries: 24 No. of Occupations: 48 No. of Employees: 115042 (estimated) No. of Female Employees: 83784 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R33
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MB7600000
HS Code 29224910

 Synthetic Route

 Customs

HS Code 29224910

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 Synonyms

1-aminomethyl-2-hydroxymethylbenzene
aminomethylbenzyl alcohol
2-Aminomethyl-1-hydroxymethylbenzene
aminomethylcarboxylic acid
carboxymethylamine
MFCD00236360
Glycine
EINECS 200-272-2
1-hydroxymethyl-2-aminomethylbenzene
H-Gly-OH
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Chemsrc provides Glycine(CAS#:56-40-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Glycine are included as well.>> amp version: Glycine

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