Aurantiamide acetate

Modify Date: 2024-01-06 08:49:36

Aurantiamide acetate structure	Common Name	Aurantiamide acetate
	CAS Number	56121-42-7	Molecular Weight	444.522
	Density	1.2±0.1 g/cm3	Boiling Point	716.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₈N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	386.9±32.9 °C

Use of Aurantiamide acetate

Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].

Name	Asperglaucide
Synonym	More Synonyms

Description	Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
In Vitro	Aurantiamide acetate inhibits cathepsin L (3.4.22.15) and cathepsin B (3.4.22.1) with IC50 of 12 μM and 49 μM, respectiveiy[1].
References	[1]. K Isshiki, et al. Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus Penicilloides. Biosci Biotechnol Biochem. 2001 May;65(5):1195-7. [2]. Chi-Su Yoon, et al. Anti-neuroinflammatory Effect of Aurantiamide Acetate From the Marine Fungus Aspergillus Sp. SF-5921: Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced Mouse BV2 Microglial Cells.Int Immunopharmacol. 2014 Dec;23(2):568-74.

Density	1.2±0.1 g/cm3
Boiling Point	716.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₈N₂O₄
Molecular Weight	444.522
Flash Point	386.9±32.9 °C
Exact Mass	444.204895
PSA	84.50000
LogP	4.58
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.587