U-46619

Modify Date: 2024-04-03 12:44:01

U-46619 structure	Common Name	U-46619
	CAS Number	56985-40-1	Molecular Weight	350.492
	Density	1.1±0.1 g/cm3	Boiling Point	519.7±30.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	176.1±18.1 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of U-46619

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1].

Name	9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Synonym	More Synonyms

Description	U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	TXA2[1]
In Vitro	U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1]. U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1]. U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1]. U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].
In Vivo	U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3]. Animal Model: 12-15 weeks-old male and female SHR[2] Dosage: 5 μg/kg Administration: Intravenous injection Result: Induceed a significant increase of MABP after 1 min in male SHR.
References	[1]. Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104. [2]. Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9(1):313. [3]. Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73.

Density	1.1±0.1 g/cm3
Boiling Point	519.7±30.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₄O₄
Molecular Weight	350.492
Flash Point	176.1±18.1 °C
Exact Mass	350.245697
PSA	66.76000
LogP	3.90
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.548

U-46619 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9681090

CHEMICAL NAME :: 5-Heptenoic acid, 7-(6-(3-hydroxy-1-octenyl)-2-oxabicyclo(2.2.1)hept-5- yl)-, (1R-(1-alpha, 4-alpha,5-beta(Z),6-alpha(1E,3S*)))-

CAS REGISTRY NUMBER :: 56985-40-1

LAST UPDATED :: 198306

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H34-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 224,369,1983

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319-H336
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F;Xi
Risk Phrases	R11;R36;R66;R67
Safety Phrases	S16;S26
RIDADR	UN 1231 3/PG 2

P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation.

Thromb. Haemost. 112(1) , 142-50, (2014)

ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influen...

Thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus through enhancing neointima formation.

PLoS ONE 9(4) , e94895, (2014)

Ductus arteriosus (DA) closure follows constriction and remodeling of the entire vessel wall. Patent ductus arteriosus occurs when the DA does not close after birth, and this condition is currently tr...

A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel.

Platelets 25(8) , 612-8, (2014)

There is wide variation in response to antiplatelet therapy and high on-treatment platelet reactivity is associated with adverse cardiovascular events. The objective here was to determine whether the ...

5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)-

(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}-5-heptenoic acid

MFCD00135238

U 46619,(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoicacid

DC Chemicals Limited
China
Product Name: U-46619
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Purity: 98.0%
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Price: ￥3300/1 mg (28.5 mM * 100 μL in Methyl acetate)

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U-46619

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U-46619 Biological Activity

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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