cholesterol

Modify Date: 2024-01-02 13:55:35

cholesterol structure	Common Name	cholesterol
	CAS Number	57-88-5	Molecular Weight	386.654
	Density	1.0±0.1 g/cm3	Boiling Point	360 ºC
	Molecular Formula	C₂₇H₄₆O	Melting Point	148-150 °C
	MSDS	Chinese USA	Flash Point	250 ºC
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of cholesterol

Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated. IC50 value:Target:In vitro: GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro produced 20-31% reductions in cellular cholesterol content, similar to the decrease in cholesterol synthesis observed in diabetes [1].In vivo:

Name	cholesterol
Synonym	More Synonyms

Description	Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated. IC50 value:Target:In vitro: GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro produced 20-31% reductions in cellular cholesterol content, similar to the decrease in cholesterol synthesis observed in diabetes [1].In vivo:
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Others Natural Products >> Steroids
Target	Human Endogenous Metabolite
References	[1]. Laverdy OG, et al. Effects of glycemic control upon serum lipids and lipid transfers to HDL in patients with type 2 diabetes mellitus: novel findings in unesterified cholesterol status. Experimental and Clinical Endocrinology & Diabetes, 2015, 123(4):232-239 [2]. Sandy Huey-Jen Hsu, et al. Validation of the Estimation of Low-density LipoproteinCholesterol by the Modified Friedewald Equation in EthnicChinese Adults Living in Taiwan. Internal Medicine, 54: 2291-2297, 2015 [3]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.

Density	1.0±0.1 g/cm3
Boiling Point	360 ºC
Melting Point	148-150 °C
Molecular Formula	C₂₇H₄₆O
Molecular Weight	386.654
Flash Point	250 ºC
Exact Mass	386.354858
PSA	20.23000
LogP	9.85
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.525
Water Solubility	negligible

cholesterol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ8400000

CHEMICAL NAME :: Cholesterol

CAS REGISTRY NUMBER :: 57-88-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C27-H46-O

MOLECULAR WEIGHT :: 386.73

WISWESSER LINE NOTATION :: L E5 B666 LUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2100 mg/kg/12W-C

TOXIC EFFECTS :: Peripheral Nerve and Sensation - recording from peripheral motor nerve Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12180 mg/kg/40W-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/43W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg/47W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 gm/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 175 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1900 mg/kg

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 1-31 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 1 umol/L

REFERENCE :: CJBBDU Canadian Journal of Biochemistry and Cell Biology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.61- 1983- Volume(issue)/page/year: 62,94,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,99,1976 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,95,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,161,1987 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80865 No. of Facilities: 1321 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 13980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80865 No. of Facilities: 4091 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 41411 (estimated) No. of Female Employees: 30220 (estimated)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary Statements	P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes	Xn
Risk Phrases	R10
Safety Phrases	S24/25-S22-S36/37
RIDADR	UN 1170 3/PG 3
WGK Germany	1
RTECS	FZ8400000
Hazard Class	3.0
HS Code	2906131000

Precursor 10
CAS#:57711-50-9 3-O-tert-Butyld... CAS#:33999-75-6 1-((cholesteryl... CAS#:7604-85-5 3β-(Triethylsil... CAS#:25092-65-3 O-allylcholesterol
CAS#:6252-45-5 3β-[(Tetrahydro... CAS#:24352-63-4 17-(1,5-dimethy... CAS#:4064-06-6 (2,2,7,7-Tetram... CAS#:1857-80-3 5α,6β-dibromoch...
CAS#:2867-93-8 3,5-Cyclocholes... CAS#:70650-16-7 cholesteryl-2-t...
DownStream 10
CAS#:601-34-3 cholesteryl pal... CAS#:35602-69-8 Cholesterol Stearate CAS#:566-93-8 Cholesta-4,6-di... CAS#:1232680-81-7 cholesteryl α- ...
CAS#:604-35-3 (-)-Cholesteryl... CAS#:601-57-0 Cholest-4-en-3-one CAS#:2469-23-0 Cholest-5-ene,3... CAS#:601-54-7 5-CHOLESTEN-3-ONE
CAS#:747-90-0 Cholesta-3,5-diene CAS#:4351-55-7 Cholesterol Formate

HS Code	2906131000

Rehmannia glutinosa (Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice.

J. Ethnopharmacol. 164 , 229-38, (2015)

Rehmannia glutinosa (Gaertn.) DC. (RG) has been widely used as traditional Chinese herbal medicine for treatment of diabetes and its complications. The polysaccharide fraction of RG has been proposed ...

G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus.

J. Neurosci. 35(6) , 2384-97, (2015)

Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, ...

Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.

J. Virol. 89(10) , 5714-23, (2015)

Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (Rd...

20-Dihydro-11-deoxycortisol

cholesterin

D5-Cholesten-3b-ol

20-Dihydro Cortexolone

3b-Hydroxy-5-cholestene

5:6-Cholesten-3b-ol

(3β)-Cholest-5-en-3-ol

δ5-Cholesten-3β-ol

cholest-5-en-3-ol, (3b)-

Cholest-5-en-3-ol (3β)-

Cholest-5-en-3b-ol

EINECS 200-353-2

5-Cholesten-3B-ol

5-Cholesten-3β-ol

Cholesterol

(3b)-cholest-5-en-3-ol

3β-Hydroxycholest-5-ene

5:6-Cholesten-3β-ol

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methyl-2-heptanyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

7α-Cholesterol

MFCD00003646

Cholest-5-en-3-ol, (3β)-

(-)-Cholesterol

Cholest-5-en-3β-ol

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: cholesterol
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: cholesterol
Price: ￥105.0/5g ￥285.0/25g ￥158.0/200mg ￥298.0/100g
Purity: 99.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Cholesterol
Price: $450.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cholesterol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: cholesterol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: cholesterol
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

Get all suppliers and price by the below link:

cholesterol suppliers

Price: ￥78/10g

Reference only. check more cholesterol price

cholesterol

Use of cholesterol

Names

cholesterol Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles2620

Synonyms