Paxilline
Modify Date: 2024-01-02 19:51:46
Paxilline structure
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Common Name | Paxilline | ||
|---|---|---|---|---|
| CAS Number | 57186-25-1 | Molecular Weight | 435.555 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 648.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H33NO4 | Melting Point | 252ºC | |
| MSDS | Chinese USA | Flash Point | 346.2±31.5 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
Use of PaxillinePaxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3]. |
| Name | Paxilline,(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one |
|---|---|
| Synonym | More Synonyms |
| Description | Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 5-50 μM (SERCA)[2], BK channel[1] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.8±55.0 °C at 760 mmHg |
| Melting Point | 252ºC |
| Molecular Formula | C27H33NO4 |
| Molecular Weight | 435.555 |
| Flash Point | 346.2±31.5 °C |
| Exact Mass | 435.240967 |
| PSA | 82.55000 |
| LogP | 3.77 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.661 |
| Storage condition | 2-8°C |
| Water Solubility | Soluble in DMSO, acetone or chloroform. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H311-H315-H318-H331-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | R23/24/25 |
| Safety Phrases | 26-36/37/39-45 |
| RIDADR | UN 2811 6 |
| WGK Germany | 3 |
| RTECS | DJ2830000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 29419090 |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:12627-35-9
CAS#:121998-08-1|
Large-conductance calcium-activated potassium current modulates excitability in isolated canine intracardiac neurons.
Am. J. Physiol. Cell Physiol. 304(3) , C280-6, (2013) We studied principal neurons from canine intracardiac (IC) ganglia to determine whether large-conductance calcium-activated potassium (BK) channels play a role in their excitability. We performed whol... |
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Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.
J. Physiol. Sci. 62(4) , 325-32, (2012) The mitochondrial calcium-activated potassium channel (mitoK(Ca)) and the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) are both involved in cardiac preconditioning. Here, we examined whe... |
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Methamphetamine inhibits voltage-gated potassium currents in NG108-15 cells: possible contribution of large-conductance calcium-activated potassium channels.
Toxicol. Lett. 223(2) , 139-45, (2013) Methamphetamine (MA), a highly abused amphetamine-like psychostimulant, has surged in popularity worldwide in the last decade. Repeated MA exposure has been shown to affect the alternative splice vari... |
| 2H-Pyrano(2'',3'':5',6')benz(1',2':6,7)indeno(1,2-b)indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)- |
| PAXILINE |
| 2H-1-Benzopyrano[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)- |
| PAXILLINE,PENICILLIUM PAXILLI |
| DPNI-caged-GABA |
| (2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(2-hydroxy-2-propanyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one |
| MFCD00083464 |
| (2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one |
| paxilline from penicillium paxilli |
| Paxilline 1 |
| Paxilline |