5'-O-DMT-5-I-2'-OMe-rU

Modify Date: 2024-01-03 03:04:19

5'-O-DMT-5-I-2'-OMe-rU Structure
5'-O-DMT-5-I-2'-OMe-rU structure
Common Name 5'-O-DMT-5-I-2'-OMe-rU
CAS Number 588691-24-1 Molecular Weight 686.49
Density N/A Boiling Point N/A
Molecular Formula C31H31IN2O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5'-O-DMT-5-I-2'-OMe-rU


2’-O-Methyl-5’-O-DMTr-5-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
Synonym More Synonyms

 5'-O-DMT-5-I-2'-OMe-rU Biological Activity

Description 2’-O-Methyl-5’-O-DMTr-5-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C31H31IN2O8
Molecular Weight 686.49
Exact Mass 686.11300
PSA 121.24000
LogP 3.44040

 Synonyms

5'-O-DMT-5-I-2'-OMe-rU
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