Thymidine, a-azido- (9CI)

Modify Date: 2024-01-09 14:10:46

Thymidine, a-azido- (9CI) Structure
Thymidine, a-azido- (9CI) structure
Common Name Thymidine, a-azido- (9CI)
CAS Number 59090-48-1 Molecular Weight 283.24
Density N/A Boiling Point N/A
Molecular Formula C10H13N5O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thymidine, a-azido- (9CI)


α-Azidothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 5-(azidomethyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Synonym More Synonyms

 Thymidine, a-azido- (9CI) Biological Activity

Description α-Azidothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C10H13N5O5
Molecular Weight 283.24
Exact Mass 283.09200
PSA 154.30000

 Synthetic Route

~85%

Thymidine, a-azido- (9CI) Structure

Thymidine, a-az...

CAS#:59090-48-1

Literature: Xu, Xiaowei; Yan, Shengyong; Hu, Jianlin; Guo, Pu; Wei, Lai; Weng, Xiaocheng; Zhou, Xiang Tetrahedron, 2013 , vol. 69, # 46 p. 9870 - 9874

~92%

Thymidine, a-azido- (9CI) Structure

Thymidine, a-az...

CAS#:59090-48-1

Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491

~%

Thymidine, a-azido- (9CI) Structure

Thymidine, a-az...

CAS#:59090-48-1

Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491

~%

Thymidine, a-azido- (9CI) Structure

Thymidine, a-az...

CAS#:59090-48-1

Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491

~%

Thymidine, a-azido- (9CI) Structure

Thymidine, a-az...

CAS#:59090-48-1

Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491

~%

Thymidine, a-azido- (9CI) Structure

Thymidine, a-az...

CAS#:59090-48-1

Literature: Shiau, George T.; Schinazi, Raymond F.; Chen, Ming S.; Prusoff, William H. Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 127 - 133

 Synonyms

5-azido-2'-O-deoxythymidine
5-azidomethyl-2'-deoxyuridine