2-Amino-6-methylheptane hydrochloride

Modify Date: 2024-01-06 11:07:08

2-Amino-6-methylheptane hydrochloride structure	Common Name	2-Amino-6-methylheptane hydrochloride
	CAS Number	5984-59-8	Molecular Weight	165.70400
	Density	N/A	Boiling Point	155ºC at 760 mmHg
	Molecular Formula	C₈H₂₀ClN	Melting Point	139-140 ºC
	MSDS	N/A	Flash Point	48.9ºC

Use of 2-Amino-6-methylheptane hydrochloride

2-Amino-6-methylheptane hydrochloride is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of octamylamine.

Name	2-Heptanamine,6-methyl-, hydrochloride (1:1)
Synonym	More Synonyms

Description	2-Amino-6-methylheptane hydrochloride is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of octamylamine.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Local anesthesia is produced by tropical application of solutions of the hydrochloride or free base of 2-Amino-6-methylheptane to rabbit's eyes. Intravenously in dogs anesthetized with pentobarbital sodium, 2-Amino-6-methylheptane hydrochloride exhibits 1/500-1/1000 the pressor activity of epinephrine. 2-Amino-6-methylheptane hydrochloride is found to cause an increase in cardiac rate and amplitude of contraction. Intravenously in dogs, anesthetized with pentobarbital sodium, doses of 0.5 to 1.0 mg per kilogram of body weight of 2-Amino-6-methylheptane hydrochloride has no detectable effect on the small intestine, detrusor of the urinary bladder, urine secretion or respiration. Intraperitoneally in rats, 2-Amino-6-methylheptane hydrochloride is found to be almost entirely devoid of a central nervous system stimulating action in non-toxic doses. No histological evidence of irritation of the tracheo-bronchial tree mucosa is noted in rabbits or rats which inhale 2-Amino-6-methylheptane free base daily for 10 and 30 days respectively[1].
References	[1]. Fellows EJ, et al. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther. 1947 Aug;90(4):351-8.

Boiling Point	155ºC at 760 mmHg
Melting Point	139-140 ºC
Molecular Formula	C₈H₂₀ClN
Molecular Weight	165.70400
Flash Point	48.9ºC
Exact Mass	165.12800
PSA	26.02000
LogP	3.66220

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MQ5075000

CHEMICAL NAME :: Hexylamine, 1,5-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 5984-59-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H19-N.Cl-H

MOLECULAR WEIGHT :: 165.74

WISWESSER LINE NOTATION :: 1Y1&3YZ1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

(1,5-dimethylhexyl)ammonium chloride

2-Amino-6-methylheptane hydrochloride

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