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5984-59-8

5984-59-8 structure
5984-59-8 structure
  • Name: 2-Amino-6-methylheptane hydrochloride
  • Chemical Name: 2-Heptanamine,6-methyl-, hydrochloride (1:1)
  • CAS Number: 5984-59-8
  • Molecular Formula: C8H20ClN
  • Molecular Weight: 165.70400
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-07-12 00:47:54
  • Modify Date: 2024-01-06 11:07:08
  • 2-Amino-6-methylheptane hydrochloride is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of octamylamine.
Name 2-Heptanamine,6-methyl-, hydrochloride (1:1)
Synonyms (1,5-dimethylhexyl)ammonium chloride
2-Amino-6-methylheptane hydrochloride
Description 2-Amino-6-methylheptane hydrochloride is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of octamylamine.
Related Catalog
In Vivo Local anesthesia is produced by tropical application of solutions of the hydrochloride or free base of 2-Amino-6-methylheptane to rabbit's eyes. Intravenously in dogs anesthetized with pentobarbital sodium, 2-Amino-6-methylheptane hydrochloride exhibits 1/500-1/1000 the pressor activity of epinephrine. 2-Amino-6-methylheptane hydrochloride is found to cause an increase in cardiac rate and amplitude of contraction. Intravenously in dogs, anesthetized with pentobarbital sodium, doses of 0.5 to 1.0 mg per kilogram of body weight of 2-Amino-6-methylheptane hydrochloride has no detectable effect on the small intestine, detrusor of the urinary bladder, urine secretion or respiration. Intraperitoneally in rats, 2-Amino-6-methylheptane hydrochloride is found to be almost entirely devoid of a central nervous system stimulating action in non-toxic doses. No histological evidence of irritation of the tracheo-bronchial tree mucosa is noted in rabbits or rats which inhale 2-Amino-6-methylheptane free base daily for 10 and 30 days respectively[1].
References

[1]. Fellows EJ, et al. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther. 1947 Aug;90(4):351-8.
Boiling Point 155ºC at 760 mmHg
Melting Point 139-140 ºC
Molecular Formula C8H20ClN
Molecular Weight 165.70400
Flash Point 48.9ºC
Exact Mass 165.12800
PSA 26.02000
LogP 3.66220

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MQ5075000
CHEMICAL NAME :
Hexylamine, 1,5-dimethyl-, hydrochloride
CAS REGISTRY NUMBER :
5984-59-8
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H19-N.Cl-H
MOLECULAR WEIGHT :
165.74
WISWESSER LINE NOTATION :
1Y1&3YZ1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,351,1947

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