Chlormethiazole hydrochloride

Modify Date: 2024-01-03 15:49:34

Chlormethiazole hydrochloride structure	Common Name	Chlormethiazole hydrochloride
	CAS Number	6001-74-7	Molecular Weight	297.52200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₉Cl₂NS	Melting Point	136 °C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Chlormethiazole hydrochloride

Clomethiazole hydrochloride is a sedative and anticonvulsant. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA)[1][2].

Name	Chlormethiazole Hydrochloride
Synonym	More Synonyms

Description	Clomethiazole hydrochloride is a sedative and anticonvulsant. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA)[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Hewitt KE, et al. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. 1994 Dec;33(12):1589-95. [2]. Cross AJ, et al. The protective action of chlormethiazole against ischaemia-induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br J Pharmacol. 1995 Apr;114(8):1625-30.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Hewitt KE, et al. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. 1994 Dec;33(12):1589-95.

[2]. Cross AJ, et al. The protective action of chlormethiazole against ischaemia-induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br J Pharmacol. 1995 Apr;114(8):1625-30.

Melting Point	136 °C
Molecular Formula	C₆H₉Cl₂NS
Molecular Weight	297.52200
Exact Mass	295.95200
PSA	57.14000
LogP	2.23800

Chlormethiazole hydrochloride MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H317-H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn
Risk Phrases	22-41-43
Safety Phrases	26-36/37/39
RIDADR	NONH for all modes of transport
HS Code	2934100090

Sulfurol

CAS#:137-00-8

~73%

Chlormethiazole...

CAS#:6001-74-7

Literature: Bagley; Thomas; Rudo; Spencer; Doorley; Ossipov; Jerussi; Benvenga; Spaulding Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 827 - 841

Precursor 1
CAS#:137-00-8 Sulfurol
DownStream 0

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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Chlormethiazole hydrochloride