Desacetyl Bisacodyl

Modify Date: 2024-01-09 23:27:34

Desacetyl Bisacodyl Structure
Desacetyl Bisacodyl structure
Common Name Desacetyl Bisacodyl
CAS Number 603-41-8 Molecular Weight 277.32
Density 1.244g/cm3 Boiling Point 462.1ºC at 760 mmHg
Molecular Formula C18H15NO2 Melting Point >200ºC (dec.)
MSDS N/A Flash Point 233.3ºC

 Use of Desacetyl Bisacodyl


Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion[1].

 Names

Name 4-[(4-hydroxyphenyl)-pyridin-2-ylmethyl]phenol
Synonym More Synonyms

 Desacetyl Bisacodyl Biological Activity

Description Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion[1].
Related Catalog
References

[1]. Fujita T, et, al. Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum. Biomed Res. 2016;37(1):13-20.  

 Chemical & Physical Properties

Density 1.244g/cm3
Boiling Point 462.1ºC at 760 mmHg
Melting Point >200ºC (dec.)
Molecular Formula C18H15NO2
Molecular Weight 277.32
Flash Point 233.3ºC
Exact Mass 277.11000
PSA 53.35000
LogP 3.67300
Index of Refraction 1.655

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SM8730000
CHEMICAL NAME :
Phenol, 4,4'-(2-pyridylmethylene)di-
CAS REGISTRY NUMBER :
603-41-8
BEILSTEIN REFERENCE NO. :
0212040
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H15-N-O2
MOLECULAR WEIGHT :
277.34
WISWESSER LINE NOTATION :
T6NJ BYR DQ&R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8550 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 28,258,1977

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

 Synonyms

4,4'-pyridin-2-ylmethanediyl-bis-phenol
EINECS 210-039-7
Deacetylbisocodyl
DDPM
La-96
deacetylbisacodyl
Dihydroxydiphenyl-pyridyl methane