Pifithrin-α, p-Nitro, Cyclic
Modify Date: 2024-01-20 09:56:07
Pifithrin-α, p-Nitro, Cyclic structure
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Common Name | Pifithrin-α, p-Nitro, Cyclic | ||
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| CAS Number | 60477-38-5 | Molecular Weight | 299.348 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H13N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Pifithrin-α, p-Nitro, CyclicPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2]. |
| Name | 2-(4-Nitrophenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole |
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| Synonym | More Synonyms |
| Description | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2]. |
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| Related Catalog | |
| In Vitro | Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α[1]. |
| In Vivo | Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM[1]. Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions)[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C15H13N3O2S |
| Molecular Weight | 299.348 |
| Exact Mass | 299.072845 |
| LogP | 5.63 |
| Index of Refraction | 1.780 |
| 2-(4-Nitrophenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole |
| Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-nitrophenyl)- |
| MFCD05670249 |