3',4'-Dihydroxyflavonol

Modify Date: 2024-01-02 11:47:03

3',4'-Dihydroxyflavonol Structure
3',4'-Dihydroxyflavonol structure
Common Name 3',4'-Dihydroxyflavonol
CAS Number 6068-78-6 Molecular Weight 270.24
Density 1.579g/cm3 Boiling Point 508.9ºC at 760 mmHg
Molecular Formula C15H10O5 Melting Point N/A
MSDS Chinese USA Flash Point 198ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of 3',4'-Dihydroxyflavonol


3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1].

 Names

Name 2-(3,4-dihydroxyphenyl)-3-hydroxychromen-4-one
Synonym More Synonyms

 3',4'-Dihydroxyflavonol Biological Activity

Description 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1].
Related Catalog
In Vitro 3',4'-Dihydroxyflavonol (DiOHF) acutely preserves nitric oxide (NO) activity in the presence of elevated reactive oxygen species (ROS). DiOHF improves NO activity in diabetes by reducing Nox2-dependent superoxide production and preventing eNOS uncoupling to improve endothelial function[1]. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized third-order branches of rat mesenteric arteries[2].
References

[1]. Leo CH, et al. 3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. PLoS One. 2011;6(6):e20813.

[2]. Kim HY, et al. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):191-202.

 Chemical & Physical Properties

Density 1.579g/cm3
Boiling Point 508.9ºC at 760 mmHg
Molecular Formula C15H10O5
Molecular Weight 270.24
Flash Point 198ºC
Exact Mass 270.05300
PSA 90.90000
LogP 2.57680
Index of Refraction 1.747

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII
HS Code 2914501900

 Synthetic Route

~69%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

~%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

~%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

~%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760

~45%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

~%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

~%

3',4'-Dihydroxyflavonol Structure

3',4'-Dihydroxy...

CAS#:6068-78-6

Literature: Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210

 Customs

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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 Synonyms

3',4'-dihydroxyflavonol
3',4'-Dihydroxyflavonol
3,3',4'-TRIHYDROXYFLAVONE
3,3',4'-trihydroxyflavon
2-(3,4-dihydroxy-phenyl)-3-hydroxy-chromen-4-one
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