Ebselen

Modify Date: 2024-01-04 17:10:20

Ebselen structure	Common Name	Ebselen
	CAS Number	60940-34-3	Molecular Weight	274.177
	Density	N/A	Boiling Point	402.8±28.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₉NOSe	Melting Point	178-181 °C
	MSDS	Chinese USA	Flash Point	197.4±24.0 °C
	Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Use of Ebselen

Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]

Name	ebselen
Synonym	More Synonyms

Description	Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology
References	[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. [2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Inflammation/Immunology

References

[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.

[2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.

Boiling Point	402.8±28.0 °C at 760 mmHg
Melting Point	178-181 °C
Molecular Formula	C₁₃H₉NOSe
Molecular Weight	274.177
Flash Point	197.4±24.0 °C
Exact Mass	274.984924
PSA	22.00000
LogP	2.04770
Vapour Pressure	0.0±0.9 mmHg at 25°C
Storage condition	2-8°C

Ebselen MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4140750

CHEMICAL NAME :: 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-

CAS REGISTRY NUMBER :: 60940-34-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H9-N-O-Se

MOLECULAR WEIGHT :: 274.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H331-H373-H410
Precautionary Statements	P261-P273-P301 + P310-P311-P501
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R23/25;R33;R50/53
Safety Phrases	S20/21-S28-S45-S60-S61-S28A
RIDADR	UN 3283 6.1/PG 3
WGK Germany	3
RTECS	DE4140750
HS Code	2927000090

HS Code	2927000090
Summary	2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.

Int. Arch. Allergy Immunol. 159(3) , 278-86, (2012)

Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiati...

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

J. Exp. Med. 212(4) , 555-68, (2015)

The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its re...

Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.

Mol. Cell. Neurosci. 67 , 116-25, (2015)

Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling molecules that mediate the dendrite promoting act...

2-Phenyl-1,2-benzoselenazol-3(2H)-one

1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-

Ebselenum

2-phenyl-1,2-benzoselenazol-3-one

Harmokisane

Ebselen

MFCD00210937

Ebseleno

Ebselene

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