![]() Bretylium (tosylate) structure
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Common Name | Bretylium (tosylate) | ||
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CAS Number | 61-75-6 | Molecular Weight | 414.357 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H24BrNO3S | Melting Point | 97-99° | |
MSDS | N/A | Flash Point | N/A | |
Symbol |
![]() GHS07 |
Signal Word | Warning |
Use of Bretylium (tosylate)Bretylium (tosylate) is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters. It is the sympathetic nerve and adrenergic ganglion blocking agent .(1) Bretylium tosylate inhibits adrenergic function presynaptically only after an initial release in neurotransmitter substance.(2) The reference for administration dose is 15 mg/kg (I.P). |
Name | bretylium tosylate |
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Synonym | More Synonyms |
Description | Bretylium (tosylate) is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters. It is the sympathetic nerve and adrenergic ganglion blocking agent .(1) Bretylium tosylate inhibits adrenergic function presynaptically only after an initial release in neurotransmitter substance.(2) The reference for administration dose is 15 mg/kg (I.P). |
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Related Catalog | |
References |
Melting Point | 97-99° |
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Molecular Formula | C18H24BrNO3S |
Molecular Weight | 414.357 |
Exact Mass | 413.066010 |
PSA | 65.58000 |
LogP | 5.02530 |
Appearance of Characters | white |
Water Solubility | H2O: soluble50mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
![]() GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 + H312 + H332 |
Precautionary Statements | P261-P280-P301 + P312 + P330 |
Hazard Codes | Xn |
Risk Phrases | 20/21/22 |
Safety Phrases | S36 |
RIDADR | NONH for all modes of transport |
RTECS | BO9450000 |
Catecholamines, α-, and β-adrenoceptors are not responsible for activation of duodenum motility induced by sympathetic nerve stimulation.
Bull. Exp. Biol. Med. 152(1) , 5-8, (2011) Stimulation of sympathetic nerve in anesthetized dogs not treated with adrenergic blockers more frequently exerted stimulating rather than inhibitory effect on duodenal motility. Blockade of α- and β-... |
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Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors.
J. Physiol. Pharmacol. 56(4) , 543-53, (2005) Pineal hormone melatonin is proposed as a potential treatment for severe sleep disturbances, and various gastrointestinal disorders. It was shown that melatonin increases intestinal motility and influ... |
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Tone of sympathetic nerves and regulation of heart activity.
Bull. Exp. Biol. Med. 130(10) , 930-3, (2000) Tone of sympathetic nerves to the heart was studied in rats and guinea pigs. Experiments with pharmacological blockade of the sympathetic nervous system and vagotomy confirmed the general notion on th... |
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