Merck-22-6
Modify Date: 2024-01-08 17:28:02
Merck-22-6 structure
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Common Name | Merck-22-6 | ||
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| CAS Number | 612847-42-4 | Molecular Weight | 653.81500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H43N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Merck-22-6Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1]. |
| Name | N-[2-(diethylamino)ethyl]-3-[4-[[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-2-phenylquinoxaline-6-carboxamide |
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| Description | Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1]. |
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| Related Catalog | |
| Target |
Akt1:138 nM (IC50) Akt2:212 nM (IC50) Akt3:7.2 mM (IC50) Caspase-3 |
| In Vitro | Akt1/Akt2-IN-2 (compound 7) 对 LnCaP，HT29，MCF7，A2780 细胞有细胞毒性[1]。 Akt1/Akt2-IN-2 (2 μM, 4 μM) 分别在2 μM和4 μM时，诱导 LnCaP 细胞中 caspase-3 的活性增加 3 倍或 6.6 倍[1]。 |
| References |
| Molecular Formula | C40H43N7O2 |
|---|---|
| Molecular Weight | 653.81500 |
| Exact Mass | 653.34800 |
| PSA | 102.90000 |
| LogP | 7.44050 |
![1-(4-((4-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-1-YL)PIPERIDIN-1-YL)METHYL)PHENYL)-2-PHENYLETHANE-1,2-DIONE structure](https://image.chemsrc.com/caspic/269/612848-74-5.png)