Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate

Modify Date: 2024-01-30 18:04:26

Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate structure	Common Name	Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate
	CAS Number	63177-57-1	Molecular Weight	194.184
	Density	1.3±0.1 g/cm3	Boiling Point	400.7±35.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₀O₄	Melting Point	178-180°C
	MSDS	Chinese USA	Flash Point	163.3±19.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate

Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity[1].

Name	Methyl 2,5-Dihydroxycinnamate
Synonym	More Synonyms

Description	Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Umezawa K, et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 1990 Jan 29;260(2):198-200.

Density	1.3±0.1 g/cm3
Boiling Point	400.7±35.0 °C at 760 mmHg
Melting Point	178-180°C
Molecular Formula	C₁₀H₁₀O₄
Molecular Weight	194.184
Flash Point	163.3±19.4 °C
Exact Mass	194.057907
PSA	66.76000
LogP	1.51
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.629
Storage condition	−20°C
Water Solubility	0.1 M NaOH: soluble

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R23/24/25
Safety Phrases	S22-S26-S36-S45
RIDADR	NONH for all modes of transport
WGK Germany	3

Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors.

Biochemistry 40(3) , 777-90, (2001)

The facilitative hexose transporter GLUT1 is a multifunctional protein that transports hexoses and dehydroascorbic acid, the oxidized form of vitamin C, and interacts with several molecules structural...

Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors.

J. Biol. Chem. 271(42) , 26418-23, (1996)

Topoisomerase II is an essential enzyme for proliferation of eukaryotic cells. It is also a target for many antineoplastic drugs that promote stabilization of covalent complexes between topoisomerase ...

Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.

Bone 23(1) , 17-26, (1998)

This investigation examined which signal pathways are of relevance in growth factor-stimulated bone cell mitogenesis. Platelet-derived growth factor (PDGF) and insulin-like growth factor-II (IGF-II) w...

2-Propenoic acid, 3-(2,5-dihydroxyphenyl)-, methyl ester, (2E)-

Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate

MFCD00132932

methyl (E)-3-(2,5-dihydroxyphenyl)prop-2-enoate