8-CPT-2Me-cAMP sodium

Modify Date: 2024-01-16 23:02:51

8-CPT-2Me-cAMP sodium structure	Common Name	8-CPT-2Me-cAMP sodium
	CAS Number	634207-53-7	Molecular Weight	525.83600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₆ClN₅NaO₆PS	Melting Point	235.5-237.5 â„ƒ(lit.)
	MSDS	N/A	Flash Point	N/A

Use of 8-CPT-2Me-cAMP sodium

8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM)[1]. 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro[2].

Name	sodium,9-[(4aR,6R,7R,7aR)-7-methoxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-8-(4-chlorophenyl)sulfanylpurin-6-amine,hydrate
Synonym	More Synonyms

Description	8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM)[1]. 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Ras
References	[1]. Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002 Nov;4(11):901-6. [2]. Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem. 2003 Mar 7;278(

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Ras

References

[1]. Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002 Nov;4(11):901-6.

[2]. Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem. 2003 Mar 7;278(

Melting Point	235.5-237.5 â„ƒ(lit.)
Molecular Formula	C₁₇H₁₆ClN₅NaO₆PS
Molecular Weight	525.83600
Exact Mass	525.02500
PSA	191.01000
LogP	3.59640