2′-Deoxy-2′-fluoroadenosine

Modify Date: 2024-01-04 12:30:45

2′-Deoxy-2′-fluoroadenosine structure	Common Name	2′-Deoxy-2′-fluoroadenosine
	CAS Number	64183-27-3	Molecular Weight	269.232
	Density	2.0±0.1 g/cm3	Boiling Point	628.6±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂FN₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	334.0±34.3 °C

Use of 2′-Deoxy-2′-fluoroadenosine

2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1].

Name	(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Synonym	More Synonyms

Description	2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.

Density	2.0±0.1 g/cm3
Boiling Point	628.6±65.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₂FN₅O₃
Molecular Weight	269.232
Flash Point	334.0±34.3 °C
Exact Mass	269.092407
PSA	119.31000
LogP	-0.32
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.834