3’-O-(2-Methoxyethyl)-2-thiouridine

Modify Date: 2024-01-27 16:02:45

3’-O-(2-Methoxyethyl)-2-thiouridine structure	Common Name	3’-O-(2-Methoxyethyl)-2-thiouridine
	CAS Number	647839-20-1	Molecular Weight	318.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₈N₂O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3’-O-(2-Methoxyethyl)-2-thiouridine

3’-O-(2-Methoxyethyl)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one

Description	3’-O-(2-Methoxyethyl)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Molecular Formula	C₁₂H₁₈N₂O₆S
Molecular Weight	318.35
Exact Mass	318.08900
PSA	138.29000

4-(2,6-dimethylphenoxy)-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)pyrimidine-2(1H)-thione structure

4-(2,6-dimethyl...

CAS#:647839-19-8

~79%

3’-O-(2-Methoxyethyl)-2-thiouridine Structure

3’-O-(2-Methoxy...

CAS#:647839-20-1

Literature: Okamoto, Itaru; Shohda, Koh-Ichiroh; Seio, Kohji; Sekine, Mitsuo Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9971 - 9982

2'-O-(2-Methoxyethyl)uridine structure

2'-O-(2-Methoxy...

CAS#:223777-15-9

~%

3’-O-(2-Methoxyethyl)-2-thiouridine Structure

3’-O-(2-Methoxy...

CAS#:647839-20-1

Literature: Okamoto, Itaru; Shohda, Koh-Ichiroh; Seio, Kohji; Sekine, Mitsuo Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9971 - 9982

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione structure

1-((2R,3R,4R,5R...

CAS#:647839-16-5

~%

3’-O-(2-Methoxyethyl)-2-thiouridine Structure

3’-O-(2-Methoxy...

CAS#:647839-20-1

Literature: Okamoto, Itaru; Shohda, Koh-Ichiroh; Seio, Kohji; Sekine, Mitsuo Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9971 - 9982

N/A structure

N/A

CAS#:647839-17-6

~%

3’-O-(2-Methoxyethyl)-2-thiouridine Structure

3’-O-(2-Methoxy...

CAS#:647839-20-1

Literature: Okamoto, Itaru; Shohda, Koh-Ichiroh; Seio, Kohji; Sekine, Mitsuo Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9971 - 9982

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-4-(2,6-dimethylphenoxy)pyrimidine-2(1H)-thione structure

1-((2R,3R,4R,5R...

CAS#:647839-18-7

~%

3’-O-(2-Methoxyethyl)-2-thiouridine Structure

3’-O-(2-Methoxy...

CAS#:647839-20-1

Literature: Okamoto, Itaru; Shohda, Koh-Ichiroh; Seio, Kohji; Sekine, Mitsuo Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9971 - 9982

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